主题：Resorcinarene-based Host Molecules Functionalized with Amino Acids and Used for Separations

报告人：Roger Harrison 

时间：2024年5月3日（周五）10：00-11：30

地点：霞光楼220

邀请人：颜徐州，研究员

个人简介

Professor Roger Harrison received his PhD from the University of Utah in 1993 after doing organometallic research with Thomas Richmond. Afterwards he did post-doctoral bioinorganic research with Lawrence Que at the University of Minnesota. In 1995 he accepted a faculty position at Brigham Young University in the Department of Chemistry and Biochemistry and is now a full professor there. He has mentored graduate students and over one hundred undergraduate students. His research group focuses on using resorcinarenes for the separation of water contaminants and synthesizing zinc oxide and magnetite nanomaterials.

报告摘要

Resorcinarenes have a rich history of molecular recognition. Their cavities can be elongated and are known to bind guest molecules. The ability of resorcinarenes to have different functional groups makes them good candidates to be used for selective binding. In the past we have synthesized resorcinarenes with metal chelating ligands.1,2 We have now turned our focus to chiral resorcinarenes with amino acids. One of these new resorcinarenes has alanine and binds aromatic amines and separates metal ions.3 Our most recent resorcinarenes contain amino acids like glutamic acid (Figure 1) and have shown the ability to separate water contaminants such as pharmaceuticals and polyfluoroalkyl substances (PFAS).4,5 As more medications are put into wastewater by our growing population, more of these drugs are ending up in drinking water. The quantification, which relies on the separation of these contaminants of emerging concern, is facilitated by resorcinarenes when they are used as packing materials in ion chromatography (IC). The synthesis of resorcinarenes with amino acids and their separations of water contaminants will be presented.